An Evaluation of Wound Healing Efficacy of a Film Dressing Made from Polymer-integrated Amnion Membrane
| Autor: | Justin Harrison, Bo Wang, Wuwei Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Embryology
Scaffold Polymers 0206 medical engineering Tibia bone Biomedical Engineering Biocompatible Materials Tissue Adhesions 02 engineering and technology Rats Sprague-Dawley 03 medical and health sciences Fibrosis Animals Humans Medicine Amnion 030304 developmental biology Wound Healing 0303 health sciences Transplantation Decellularization Tissue Scaffolds business.industry Regeneration (biology) medicine.disease Bandages 020601 biomedical engineering Rats Disease Models Animal medicine.anatomical_structure Wound dressing business Wound healing Research Paper Developmental Biology Biomedical engineering |
| Zdroj: | Organogenesis |
| ISSN: | 1555-8592 1547-6278 |
| DOI: | 10.1080/15476278.2020.1844507 |
| Popis: | A film dressing is an easy and common wound management, which is flexible to cover many types of superficial injuries. In a recent study, we developed a scaffold from poly (1,8-octanediolco-citrate) incorporated decellularized amnion membrane (DAM-POC). The DAM-POC scaffold was biocompatible and could enhance soft and hard tissue regeneration when applied to repair the cleft palate in rat. The efficacy of the DAM-POC scaffold in oral repair had led us to hypothesize that it could be employed extensively in the medical field as a wound dressing. This study aimed to investigate the feasibility and efficacy of the DAM-POC scaffold as a film dressing in accelerating wound healing when applied in multiple tissue injuries. Our results demonstrated that both the DAM and DAM-POC scaffolds were biocompatible and anti-adhesive without causing severe foreign body reactions when covering wounds in abdominal wall, back muscle, tibia bone, and liver. In addition, the DAM-POC scaffold was superior to the DAM scaffold in reducing inflammation, preventing fibrosis, and regenerating tissues. In conclusion, the DAM-POC scaffold might potentially be adopted as a film dressing in a wide range of therapeutic applications and healing situations to protect the damaged tissues from the external environment and prevent infections. |
| Databáze: | OpenAIRE |
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