c-Jun interacts with phospholipids and c-Fos at the interface
| Autor: | Maximiliano Del Boca, Bruno Maggio, Beatriz L. Caputto, Graciela A. Borioli |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
biology
Chemistry Proto-Oncogene Proteins c-jun Surface Properties c-jun Complex formation medicine.disease_cause c-Fos Binding Competitive Surfaces Coatings and Films Electronic Optical and Magnetic Materials Biomaterials Transcription Factor AP-1 Colloid and Surface Chemistry Biochemistry Transcription (biology) Monolayer biology.protein Biophysics medicine Carcinogenesis Transcription factor Proto-Oncogene Proteins c-fos Phospholipids Protein Binding |
| Zdroj: | Journal of colloid and interface science. 287(1) |
| ISSN: | 0021-9797 |
| Popis: | We describe c-Jun, a widely studied transcription factor that participates in cell proliferation, differentiation, and tumorigenesis, as amphitropic. We show that c-Jun forms stable monolayers and interacts favorably, although in a nonselective manner, with phospholipids at the interface. The surface activity of c-Jun, together with that of c-Fos, its common partner in AP-1 transcription heterodimers, drives interfacial complex formation. We show that AP-1 is very stable at the air–water interface and suggest that AP-1 may not be substantially formed in solution as a stable equimolar association of both proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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