Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes
Autor: | Myung Ho Jeong, Christophe Piot, Jérôme Rischner, Fernando Lozano, Tae Hoon Ahn, Bruno García del Blanco, Victoria Vilalta del Olmo, Byung-Chun Jung, Peter Krajči, Petr Tousek, Matthias Waliszewski, Lucie Wachowiak, Koldobika Garcia-San Roman, Michel Pansieri, Matthias Leschke, Eduard Fernandez Nofrerias, Kyu-Rock Han, Wan Azman Wan Ahmad, Milan Trenčan, Laurent Sebagh, Bronislav Janek, Viktor Kočka, Imanol Otaegui Irurueta, Florian Krackhardt |
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Přispěvatelé: | Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], B. Braun Melsungen AG, University of Malaya [Kuala Lumpur, Malaisie], University Hospital Kralovské Vinohrady, Institute for Clinical and Experimental Medicine (IKEM), Matej Bel University (UMB), Hospital General de Ciudad Real (HGUCR), University of Castilla-La Mancha (UCLM), Hospital Universitario Cruces = Cruces University Hospital, Vall d'Hebron University Hospital [Barcelona], B. Braun Medical (Saint-Cloud), Hospital Universitario Germans Trias I Pujol, Chonnam National University [Gwangju], Daegu Fatima Hospital, Kangdong Sacred Heart Hospital, Hallym University, Clinique du Millénaire - Oc Santé [Montpellier], Oc Santé [Montpellier], Clinique Turin, Hôpital Albert Schweitzer, Centre Hospitalier Henri Duffaut (Avignon), Städtische Kliniken, Gachon University Gil Medical Center [Incheon, Republic of Korea] |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Cardiovascular Procedures Epidemiology Polymers medicine.medical_treatment Myocardial Infarction Coronary Artery Disease 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Antiplatelet Therapy Geographical Locations Coronary artery disease Endocrinology 0302 clinical medicine MESH: Mediterranean Region Medicine and Health Sciences Ethnicity Clinical endpoint Prospective Studies 030212 general & internal medicine MESH: Coronary Artery Disease MESH: Incidence Prospective cohort study MESH: Aged Multidisciplinary MESH: Middle Aged Pharmaceutics Mediterranean Region Incidence Incidence (epidemiology) Drug-Eluting Stents MESH: Follow-Up Studies Middle Aged Prognosis 3. Good health MESH: Polymers Europe MESH: Malaysia MESH: Myocardial Infarction Medicine Female MESH: Ethnic Groups MESH: Immunosuppressive Agents MESH: Percutaneous Coronary Intervention Immunosuppressive Agents Research Article MESH: Drug-Eluting Stents MESH: Republic of Korea medicine.medical_specialty Asia Coronary Stenting Endocrine Disorders Science Surgical and Invasive Medical Procedures MESH: Prognosis Ethnic Epidemiology 03 medical and health sciences Signs and Symptoms Percutaneous Coronary Intervention Drug Therapy [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Diagnostic Medicine South Korea Internal medicine Angioplasty Republic of Korea Diabetes Mellitus medicine Humans Aged Sirolimus MESH: Humans business.industry Malaysia Stent medicine.disease MESH: Male MESH: Prospective Studies Metabolic Disorders People and Places Stent Implantation Lesions Observational study [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Sirolimus MESH: Europe business MESH: Female Mace Follow-Up Studies |
Zdroj: | PLoS ONE, Vol 15, Iss 1, p e0226606 (2020) PLoS ONE PLoS ONE, Public Library of Science, 2020, 15 (1), pp.e0226606. ⟨10.1371/journal.pone.0226606⟩ r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0226606⟩ |
Popis: | Background The objective of this study was to assess regional and ethnic differences in an unselected patient population treated with polymer-free sirolimus-eluting stents (PF-SES) in Asia and Europe. Methods Two all-comers observational studies based on the same protocol (ClinicalTrials.gov Identifiers: NCT02629575 and NCT02905214) were combined for data analysis to assure sufficient statistical power. The primary endpoint was the accumulated target lesion revascularization (TLR) rate at 9-12 months. Results Of the total population of 7243 patients, 44.0% (3186) were recruited in the Mediterranean region and 32.0% (2317) in central Europe. The most prominent Asian region was South Korea (17.6%, 1274) followed by Malaysia (5.7%, 413). Major cardiovascular risk factors varied significantly across regions. The overall rates for accumulated TLR and MACE were low with 2.2% (140/6374) and 4.4% (279/6374), respectively. In ACS patients, there were no differences in terms of MACE, TLR, MI and accumulated mortality between the investigated regions. Moreover, dual antiplatelet therapy (DAPT) regimens were substantially longer in Asian countries even in patients with stable coronary artery disease as compared to those in Europe. Conclusions PF-SES angioplasty is associated with low clinical event rates in all regions. Further reductions in clinical event rates seem to be associated with longer DAPT regimens. |
Databáze: | OpenAIRE |
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