Targeting Collagen Type III in Proteinuric Kidney Disease: Informing Drug Potential Using the Jaccard–Tanimoto Index
| Autor: | Kai Jiang, Natalia Prakash, Anthony J Pellicano, Anoushka Dalvi, Sony Dalapati, Ping Zhou, Itzhak D. Goldberg, Zhijian Hu, Michelle Liu, Prakash Narayan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
kidney Pathology medicine.medical_specialty medicine 030232 urology & nephrology glomerulus Bioengineering Glomerulus (kidney) lcsh:Chemical technology urologic and male genital diseases Nephropathy lcsh:Chemistry collagen type III 03 medical and health sciences Collagen Type III 0302 clinical medicine Chemical Engineering (miscellaneous) lcsh:TP1-1185 urogenital system business.industry Process Chemistry and Technology Glomerular mesangium drug transcriptomic Collagenofibrotic glomerulopathy Glomerular Hypertrophy medicine.disease female genital diseases and pregnancy complications 030104 developmental biology medicine.anatomical_structure lcsh:QD1-999 Mesangium precision proteinuria business discovery Kidney disease |
| Zdroj: | Processes Volume 8 Issue 8 Processes, Vol 8, Iss 996, p 996 (2020) |
| ISSN: | 2227-9717 |
| DOI: | 10.3390/pr8080996 |
| Popis: | Collagenofibrotic glomerulopathy, a collagen type III kidney disease, is associated with proteinuria and accumulation ofcollagen type III in the glomerulus specifically the mesangium and/or capillary walls. The puromcyin aminonucleoside (PAN) nephropathy model was evaluated to examine the relation between COL3A1 mRNA and proteinuria. In Wistar rats administered PAN, a robust increase in proteinuria was accompanied by glomerular hypertrophy and expansion of both the Bowman&rsquo s capsule and Bowman&rsquo s space. An ~4-fold increase in renal COL3A1 mRNA was observed in the PAN cohort with urine protein exhibiting a direct (r = 0.8) and significant correlation with kidney COL3A1 mRNA level. Both Picrosirius red polarized microscopy and immunohistochemical analysis showed localization of collagen type III to the glomerular mesangium. Gene ontology-driven transcriptomic analysis reveals a robust COL3A1 network in the glomerular compartment. |
| Databáze: | OpenAIRE |
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