Proteasome activity in tumors of the female reproductive system
| Autor: | Elena M. Slonimskaya, I. V. Kondakova, E. E. Shashova, L. V. Spirina, V. D. Koval, A. L. Chernyshova, L. A. Kolomiets |
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| Rok vydání: | 2012 |
| Předmět: |
Proteasome Endopeptidase Complex
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Female reproductive system Biology medicine.disease_cause Biochemistry Targeted therapy Breast cancer Internal medicine medicine Humans Neoplasm Invasiveness Protease Inhibitors Lymph node Endometrial cancer Organic Chemistry Cancer Middle Aged medicine.disease Endometrial Neoplasms medicine.anatomical_structure Endocrinology Proteasome Lymphatic Metastasis Cancer research Female Carcinogenesis Proteasome Inhibitors |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 38:89-92 |
| ISSN: | 1608-330X 1068-1620 |
| Popis: | Proteasomes (multiproteinase protein complexes) are known to play an important role in cancer pathogenesis, however, few information about their activity in human tumor tissues is available so far. We studied chymotrypsin-like activity of proteasomes in tissues of breast cancer (BC) and endometrial cancer (EC). The chymotrypsin-like total proteasome activity and the 20S and 26S proteasome activity in malignant tissues were shown to be significantly higher in malignant tumors than in normal tissues. No increase in proteasome activity was registered with larger tumor size in both BC and EC, whereas proteasome activity was changed with respect to the extent of tumor involvement. In breast cancer tissues, significant reductions in the total and the 26S proteaome activities were observed in tumors with regional lymph node metastases as compared to tumors without metastases. In endometrial cancer tissues, the total proteasome activity and the 20S and 26S proteasome activities were increased as the depth of myometrial invasion. The data obtained indicate that the proteasome acyivity is significantly changed in the process of cancerogenesis and further study is needed to develop new additional prognostic criteria and effective anti-tumor agents in molecular-directed therapy. |
| Databáze: | OpenAIRE |
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