Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes: A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort
| Autor: | Nanna B. Finnerup, Søren Tang Knudsen, Brian C. Callaghan, Henning Andersen, Reimar W. Thomsen, Lotte Brix Christensen, Henrik Toft Sørensen, Henning Beck-Nielsen, Sandra Sif Gylfadottir, Eva L. Feldman, Troels S. Jensen, Jens Steen Nielsen, Diana Hedevang Christensen |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Denmark Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Cohort Studies Habits 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetic Neuropathies Risk Factors Surveys and Questionnaires Internal medicine Diabetes mellitus Prevalence Internal Medicine medicine Humans Obesity 030212 general & internal medicine Life Style Aged Advanced and Specialized Nursing business.industry Middle Aged medicine.disease Diabetes Mellitus Type 2 Neuropathic pain Cohort Disease Progression Neuralgia Female Metabolic syndrome business Polyneuropathy |
| Zdroj: | Christensen, D H, Knudsen, S T, Gylfadottir, S S, Christensen, L B, Nielsen, J S, Beck-Nielsen, H, Sørensen, H T, Andersen, H, Callaghan, B C, Feldman, E L, Finnerup, N B, Jensen, T S & Thomsen, R W 2020, ' Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes : A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort ', Diabetes Care, vol. 43, no. 6, pp. 1266-1275 . https://doi.org/10.2337/dc19-2277 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc19-2277 |
| Popis: | OBJECTIVE To investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes. RESEARCH DESIGN AND METHODS We thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we sent a detailed questionnaire on neuropathy, including the Michigan Neuropathy Screening Instrument questionnaire (MNSIq), to identify possible DPN (score ≥4) and the Douleur Neuropathique en 4 Questions (DN4) questionnaire for possible associated neuropathic pain (MNSIq ≥4 + pain in both feet + DN4 score ≥3). RESULTS Among 5,249 patients with data on both DPN and pain, 17.9% (n = 938) had possible DPN, including 7.4% (n = 386) with possible neuropathic pain. In regression analyses, central obesity (waist circumference, waist-to-hip ratio, and waist-to-height ratio) was markedly associated with DPN. Other important metabolic factors associated with DPN included hypertriglyceridemia ≥1.7 mmol/L, adjusted prevalence ratio (aPR) 1.36 (95% CI 1.17; 1.59); decreased HDL cholesterol CONCLUSIONS Possible DPN was associated with metabolic syndrome factors, insulin resistance, inflammation, and modifiable lifestyle habits in early type 2 diabetes. |
| Databáze: | OpenAIRE |
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