Understanding the Pharmaceutical Aspects of Dendrimers for the Delivery of Anticancer Drugs
Autor: | Amit Alexander, Mukta Agrawal, Sanjay Tiwari, Swarnlata Saraf, Gautam Singhvi, Shubham Salunkhe, Sunil Kumar Dubey, Maithili Kali, Shailendra Saraf |
---|---|
Rok vydání: | 2019 |
Předmět: |
Drug
Dendrimers media_common.quotation_subject Clinical Biochemistry Nanoparticle Nanotechnology Antineoplastic Agents 02 engineering and technology 010402 general chemistry 01 natural sciences Drug Delivery Systems In vivo Dendrimer Neoplasms Drug Discovery Animals Humans media_common Pharmacology Drug Carriers Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Targeted drug delivery Covalent bond Drug delivery Molecular Medicine Surface modification Nanoparticles 0210 nano-technology |
Zdroj: | Current drug targets. 21(6) |
ISSN: | 1873-5592 |
Popis: | Dendrimers are emerging class of nanoparticles used in targeted drug delivery systems. These are radially symmetric molecules with well-defined, homogeneous, and monodisperse structures. Due to the nano size, they can easily cross the biological membrane and increase bioavailability. The surface functionalization facilitates targeting of the particular site of action, assists the high drug loading and improves the therapeutic efficiency of the drug. These properties make dendrimers advantageous over conventional drug delivery systems. This article explains the features of dendrimers along with their method of synthesis, such as divergent growth method, convergent growth method, double exponential and mixed method, hyper-core and branched method. Dendrimers are effectively used in anticancer delivery and can be targeted at the site of tumor either by active or passive targeting. There are three mechanisms by which drugs interact with dendrimers, and they are physical encapsulation, electrostatic interaction, chemical conjugation of drug molecules. Drug releases from dendrimer either by in vivo cleavage of the covalent bond between drugdendrimer complexes or by physical changes or stimulus like pH, temperature, etc. |
Databáze: | OpenAIRE |
Externí odkaz: |