Survival and Prognostic Factors of Anaplastic Thyroid Carcinoma
| Autor: | J. Marinkovic, Aleksandar Diklic, Vladan Zivaljevic, Sandra Sipetic, D. V. Savic, Goran Zoric, Ivan Paunovic |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Multivariate analysis Kaplan-Meier Estimate Thyroid Carcinoma Anaplastic Risk Assessment Disease-Free Survival Cohort Studies Thyroid carcinoma Sex Factors Risk Factors Cause of Death Internal medicine Biopsy medicine Humans Neoplasm Invasiveness Thyroid Neoplasms Survival rate Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Cause of death Analysis of Variance medicine.diagnostic_test Proportional hazards model business.industry Biopsy Needle Age Factors Retrospective cohort study General Medicine Middle Aged Prognosis Combined Modality Therapy Immunohistochemistry Surgery Survival Rate Logistic Models Thyroidectomy Female business Cohort study |
| Zdroj: | Acta Chirurgica Belgica. 115:62-67 |
| ISSN: | 0001-5458 |
| Popis: | Anaplastic thyroid carcinoma (ATC) is relatively rare and represents one of the most aggressive tumours with poor prognosis, despite therapy. The aim of the study was to analyse demographic and clinical characteristics of ATC patients, and to identify survival rates and prognostic factors.In a retrospective study (1995-2005) ATC was found in 150 patients treated at our institution. Survival was calculated by Kaplan-Meier curve and log-rank test. Potential prognostic factors affecting survival were compared by Cox univariate and multivariate analyses.Mean survival time was 56 weeks; median survival time was 16 weeks and 1 and 5-year survival were 17% and 8%. More than 10% died during the first month and 50% died up to the fourth month. Multivariate analysis showed that age, goitre and surgery were independent prognostic factors of survival in all ATC patients. Among operated patients, the extent of tumour resection, distant metastasis and multicentricity were independent prognostic risk factors of survival. Postoperative radiotherapy was a protective factor.There is still no successful treatment of ATC that can guarantee long term survival. Younger patients with pre-existing goitre, who undergo complete resection of unilocular early stage ATC without distant metastasis and with postoperative external radiotherapy, stand a better chance of long-term survival. |
| Databáze: | OpenAIRE |
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