Differential effect of desglycinamide9-(Arg8)-vasopressin on cognitive functions of diabetes insipidus and alcoholic patients
| Autor: | Gábor L. Kovács, F. Laczi, A. Szász, D. de Wied, J. Szilárd, G. Telegdy, J.M. van Ree, F. A. László |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasopressin Endocrinology Diabetes and Metabolism medicine.medical_treatment Peptide hormone Affect (psychology) Severe cognitive impairments Cognition Endocrinology Alcohol Amnestic Disorder Double-Blind Method Internal medicine medicine Humans Administration Intranasal Aged Clinical Trials as Topic Psychological Tests Chemotherapy business.industry General Medicine Middle Aged medicine.disease Arginine Vasopressin Alcoholism Blood pressure Diabetes insipidus Female business Diabetes Insipidus |
| Zdroj: | Acta Endocrinologica. 115:392-398 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.1150392 |
| Popis: | Intranasal treatment with desglycinamide9-(Arg8)-vasopressin (DGAVP) improved certain aspects of cognitive functions of patients with acquired and congenital diabetes insipidus and of alcoholic patients with mild cognitive impairments. Patients with Korsakoff's syndrome, presenting with severe cognitive impairments, were resistent to DGVP treatment. DGAVP treatment did not affect blood pressure and water metabolism. The action of DGAVP on cognitive functions is probably mediated by centrally located target sites and may be expressed only in patients in whom these target sites are unimpaired. |
| Databáze: | OpenAIRE |
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