Neisseria gonorrhoeae: DNA Repair Systems and Their Role in Pathogenesis

Autor:	Viktoriia Yu. Savitskaya, Mayya V. Monakhova, Iuliia V. Iakushkina, Irina I. Borovikova, Elena A. Kubareva
Rok vydání:	2022
Předmět:	MutL Proteins DNA Repair Biophysics Humans General Medicine Fimbriae Proteins Geriatrics and Gerontology Biochemistry Biochemistry Genetics and Molecular Biology (miscellaneous) Antigenic Variation Neisseria gonorrhoeae
Zdroj:	Biochemistry. Biokhimiia. 87(9)
ISSN:	1608-3040
Popis:	Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative agent of gonorrhea, a sexually transmitted infection. The bacterium uses various approaches for adapting to environmental conditions and multiplying efficiently in the human body, such as regulation of expression of gene expression of surface proteins and lipooligosaccharides (e.g., expression of various forms of pilin). The systems of DNA repair play an important role in the bacterium ability to survive in the host body. This review describes DNA repair systems of N. gonorrhoeae and their role in the pathogenicity of this bacterium. A special attention is paid to the mismatch repair system (MMR) and functioning of the MutS and MutL proteins, as well as to the role of these proteins in regulation of the pilin antigenic variation of the N. gonorrhoeae pathogen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27275f3194f10f8d3a8c276e191cc415 https://pubmed.ncbi.nlm.nih.gov/36180987 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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