Microdialysis study of ischemia-induced hydroxyl radicals in the canine heart
| Autor: | Alexander A. Timoshin, Kuz'min Ai, Medvedev Os, Tskitishvili Ov, L. I. Serebryakova, Enno K. Ruuge |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Microdialysis Radical Myocardial Ischemia Ischemia chemistry.chemical_element Oxygen Cyclic N-Oxides Cellular and Molecular Neuroscience chemistry.chemical_compound Dogs medicine Animals Molecular Biology Pharmacology Spin trapping biology Hydroxyl Radical Chemistry Fissipedia Electron Spin Resonance Spectroscopy Cell Biology medicine.disease biology.organism_classification Reperfusion Injury Anesthesia Circulatory system Biophysics Molecular Medicine Female Spin Labels Hydroxyl radical |
| Zdroj: | Experientia. 50:677-679 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01952872 |
| Popis: | A new experimental approach for spin-trapping of oxygen radicals in a selected region of the heart in situ is described. This approach is based on microdialysis, and it permits the detection of oxygen radicals in conditions of local ischemia and restoration of normal blood flow. Increased hydroxyl radical generation in an ischemic area of canine myocardium, as a result of 40 min local occlusion, has been studied. |
| Databáze: | OpenAIRE |
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