Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice

Autor:	Norma N. Zamora, Brandon L. Warren, Sergio D. Iñiguez, Bryan Cruz, Steven J. Nieto, Kristi L Shawhan, Genesis Dayrit, Lace M. Riggs
Rok vydání:	2014
Předmět:	Dominance-Subordination Male Aging Sucrose medicine.medical_specialty Physiology Anxiety Article Social defeat Food Preferences Behavioral Neuroscience chemistry.chemical_compound Blood serum Corticosterone Internal medicine Dietary Carbohydrates medicine Animals Interpersonal Relations Psychiatry Swimming Depressive Disorder Depression Endocrine and Autonomic Systems Anhedonia medicine.disease Social relation Mice Inbred C57BL Psychiatry and Mental health Phenotype Neuropsychology and Physiological Psychology Endocrinology chemistry Major depressive disorder medicine.symptom Psychology Behavioural despair test
Zdroj:	Stress. 17:247-255
ISSN:	1607-8888 1025-3890
Popis:	Exposure to stress is highly correlated with the emergence of mood-related illnesses. Because major depressive disorder often emerges in adolescence, we assessed the effects of social defeat stress on responses to depressive-like behaviors in juvenile mice. To do this, postnatal day (PD) 35 male c57BL/6 mice were exposed to 10 days of social defeat stress (PD35-44), while control mice were handled daily. Twenty-four hours after the last episode of defeat (PD45), separate groups of mice were tested in the social interaction, forced swimming, sucrose preference, and elevated plus-maze behavioral assays (n = 7-12 per group). Also, we examined body weight gain across days of social defeat and levels of blood serum corticosterone 40 min after the last episode of defeat stress. Our data indicates that defeated mice exhibited a depressive-like phenotype as inferred from increased social avoidance, increased immobility in the forced swim test, and reduced sucrose preference (a measure of anhedonia), when compared to non-defeated controls. Defeated mice also displayed an anxiogenic-like phenotype when tested on the elevated plus-maze. Lastly, stressed mice displayed lower body weight gain, along with increased blood serum corticosterone levels, when compared to non-stressed controls. Overall, we show that in adolescent male c57BL/6 mice, social defeat stress induces a depression- and anxiety-like phenotype 24 h after the last episode of stress. These data suggest that the social defeat paradigm may be used to examine the etiology of stress-induced mood-related disorders during adolescence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2725decb68e4a075a97d87a09d2b8de0 https://doi.org/10.3109/10253890.2014.910650 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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