Prognostic significance of miR-34 rs4938723 T > C polymorphism in triple negative breast cancer patients
| Autor: | C Andreas Lazaris, George C. Zografos, Despoina Kalapanida, Konstantinos Dimitrakakis, Eleni Zografos, Andriani Tsiakou, Flora Zagouri, Spyros Marinopoulos, Maria Gazouli, Dimitrios Rigopoulos, Aris Giannos, George Samelis |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
030213 general clinical medicine medicine.medical_specialty Genotype Clinical Biochemistry Triple Negative Breast Neoplasms Single-nucleotide polymorphism Kaplan-Meier Estimate 030204 cardiovascular system & hematology Polymorphism Single Nucleotide Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor Humans Medicine Genetic Predisposition to Disease Allele Genotyping Triple-negative breast cancer Aged business.industry Proportional hazards model Histology General Medicine Middle Aged Prognosis Ductal Breast Carcinoma MicroRNAs Female business |
| Zdroj: | Clinical Biochemistry. 68:9-14 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2019.03.009 |
| Popis: | OBJECTIVES The aim of this was the assessment of the prognostic role of the rs4938723 C > T polymorphism of the miR-34 in triple negative breast cancer patients. METHODS Therefore formalin fixed paraffin embedded tissue samples from 114 triple negative breast cancer patients and blood samples from 124 healthy donors were genotyped and subsequently extensive statistical analysis was performed in order to investigate the clinical value of this polymorphism in triple negative breast cancer. RESULTS Our statistical analysis disclosed that the majority of patients harboring ductal breast carcinoma (69.4%) have the TC or CC genotypes (P = .020). Moreover the survival of the patients was significantly correlated with the occurrence of the TC or CC alleles (P |
| Databáze: | OpenAIRE |
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