Real-world effectiveness of peginterferon α-2b plus ribavirin in a Canadian cohort of treatment-naïve chronic hepatitis C patients with genotypes 2 or 3: results of the PoWer and RediPEN studies
| Autor: | M. Drolet, Magdy Elkashab, M. Poliquin, Robert J Bailey, Paul Marotta, Helga Witt-Sullivan, Kevork M. Peltekian, S. V. Feinman, E. Rampakakis, J. Farley, Curtis Cooper |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology Hepacivirus medicine.disease_cause Polyethylene Glycols chemistry.chemical_compound 0302 clinical medicine Pegylated interferon Recurrence 030212 general & internal medicine Prospective Studies Prospective cohort study Aged 80 and over education.field_of_study General Medicine Hepatitis C Middle Aged Recombinant Proteins Infectious Diseases Treatment Outcome Cohort 030211 gastroenterology & hepatology Female Original Article medicine.drug Microbiology (medical) Adult medicine.medical_specialty Canada Genotype Hepatitis C virus Population Interferon alpha-2 Antiviral Agents 03 medical and health sciences Young Adult Internal medicine Ribavirin medicine Humans education Aged business.industry Interferon-alpha Odds ratio Hepatitis C Chronic medicine.disease chemistry business |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 1435-4373 |
| Popis: | The purpose of this investigation was to assess the real-life effectiveness of pegylated interferon (peg-IFN) α-2b with ribavirin (RBV) in a cohort of treatment-naive patients with chronic genotypes 2 (G2) or 3 (G3) hepatitis C virus (HCV) infection. A post-hoc pooled analysis of two Canadian multicenter, observational studies, RediPEN and PoWer, was carried out. A total of 1242 G2- or G3-infected patients were included. The primary outcome was sustained virologic response (SVR). Secondary endpoints included early virologic response (EVR), end-of-treatment (EOT) response, and relapse. Multivariate logistic regression was used to identify independent predictors of treatment response. SVR in G2 and G3 was 74.4 % and 63.6 %, respectively. Relapse occurred in 12.7 % and 19.1 % of G2- and G3-infected patients achieving EOT response, respectively. Overall, G3 was found to independently predict reduced SVR [odds ratio (OR) = 0.20; p = 0.007] and increased relapse (OR = 6.84; p = 0.022). Among G3-infected patients, increasing fibrosis score was the most important factor predicting reduced SVR [F2 vs. F0/F1 (OR = 0.41; p = 0.009); F3 vs. F0/F1 (OR = 0.72; p = 0.338); F4 vs. F0/F1 (OR = 0.27; p = 0.001)]. Male gender (OR = 13.16; p = 0.020) and higher fibrosis score [F2 vs. F0/F1 (OR = 9.72; p = 0.016); F3/F4 vs. F0/F1 (OR = 4.23; p = 0.113)] were associated with increased relapse in G3 patients. These results support the real-life effectiveness of peg-IFN α-2b plus ribavirin in HCV G2- and G3-infected patients. Overall, genotype was identified as the most significant predictor of treatment outcome. Fibrosis score and gender were key outcome predictors in the G3-infected population. In clinical settings, peg-INF/RBV offers an alternative for patients without access to all oral direct-acting antivirals. |
| Databáze: | OpenAIRE |
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