Outcomes of stage 1-5 chronic kidney disease in Mainland China
| Autor: | Lian He, Xuan Lai, Tao Wang, Min-Hua Fan, Shao-Yan Chen, Ai-Hua Zhang, Chun-Yan Su |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty China medicine.medical_treatment Renal function urologic and male genital diseases Critical Care and Intensive Care Medicine Infections End stage renal disease Diabetic nephropathy Hemoglobins Risk Factors Internal medicine Cause of Death Neoplasms medicine Humans Diabetic Nephropathies Prospective Studies Renal Insufficiency Chronic Intensive care medicine Prospective cohort study Kidney transplantation Dialysis Cause of death Aged business.industry General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications Proteinuria Nephrology Cardiovascular Diseases Disease Progression Kidney Failure Chronic Female business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Renal failure. 36(4) |
| ISSN: | 1525-6049 |
| Popis: | This study aims to quantify and compare the risks of death and end stage renal disease (ESRD) in a prospective cohort of patients with chronic kidney disease (CKD) stages 1-5 under renal management clinic at Peking University Third Hospital and to evaluate the risk factors associated with these two outcomes.This was a prospective cohort study. Finally, 1076 patients at CKD stage 1-5 short of dialysis were recruited from renal management clinic. Patients were monitored for up to Dec, 2011 or until ESRD and death. Glomerular filtration rate was estimated (eGFR) according to the using the CKD Epidemiology Collaboration (CKD-EPI) formula.At the end of follow-up, 111 patients (10.1%) developed ESRD (initiated dialysis or kidney transplantation (ESRD)) and 24 patients (2.2%) had died. There were more ESRD occurrence rate in patients with baseline diabetic nephropathy, lower eGFR, hemoglobin100 g/L and 24 h urinary protein excretion ≥ 3.0 g. By multivariate Cox regression model, having heavy proteinuria and CKD stage were the risk factors of ESRD. For all-cause mortality, the most common cause was cardiovascular disease, followed by infectious disease and cancer. But we failed to conclude any significant variable as risk factors for mortality in multivariate analysis.Our study indicated that baseline diabetic nephropathy, lower hemoglobin level, lower baseline GFR and heavy proteinuria were the risk factors of ESRD. In this CKD cohort, patients were more likely to develop ESRD than mortality, and cardiovascular mortality was the leading cause of death, and then followed by infectious diseases and cancer in this population. |
| Databáze: | OpenAIRE |
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