Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Autor:	Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester, Lanlan Jing, Renato H. Weiße, Yusen Cheng, Norbert Sträter, Laura Schäkel, Michael Gütschow, Bing Ye, Mianling Yang, Tao Zhang, Dongwei Kang, Karoly Toth, John Tavis, Ann E. Tollefson, Christa E. Müller, Peng Zhan, Xinyong Liu
Rok vydání:	2022
Předmět:	Molecular Docking Simulation SARS-CoV-2 Drug Discovery Humans COVID-19 Molecular Medicine Protease Inhibitors Viral Nonstructural Proteins Antiviral Agents Piperazines
Zdroj:	Journal of Medicinal Chemistry. 65:16902-16917
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.2c01716
Popis:	The spread of SARS-CoV-2 keeps threatening human life and health, and small-molecule antivirals are in demand. The main protease (M
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271ca8882f9f7b9c5ad53b93c3b5bbee https://doi.org/10.1021/acs.jmedchem.2c01716 Zobrazit plný text záznamu