Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children
| Autor: | Carlo Saitta, Stefania Riggio, N. Camarda, T. Arrigo, Scipione Carerj, Raffaella Iudicello, Antonino Saitta, M.A. Sardo, Giuseppe Mandraffino, Angela Alibrandi, Egidio Imbalzano |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry Hypercholesterolemia Hemodynamics Blood Pressure Familial hypercholesterolemia Biochemistry Body Mass Index Heart Rate Internal medicine Medicine Humans Child Pulse Pulse wave velocity medicine.diagnostic_test business.industry General Medicine medicine.disease Lipids Compliance (physiology) Endocrinology Blood pressure Carotid Arteries Intima-media thickness Hypertension Arterial stiffness Cardiology atherosclerosis augmentation index hypercholesterolemia intima-media thickness pulse wave velocity Female business Lipid profile Tunica Intima Tunica Media Blood Flow Velocity Compliance |
| Zdroj: | European journal of clinical investigation. 40(3) |
| ISSN: | 1365-2362 |
| Popis: | Eur J Clin Invest 2010; 40 (3): 250–257 Abstract Background Arterial stiffness is an important determinant of cardiovascular risk. It is associated with several cardiovascular risk factors, including hypertension, diabetes and cigarette smoking. However, there are conflicting data about the relationship between arterial stiffness and hypercholesterolemia. Furthermore, augmentation index (AIx), a measure of systemic arterial stiffness, has not been previously investigated in hypercholesterolemic (HCh) children. Aim of our study was to evaluate local and systemic arterial stiffness as well as carotid intima-media thickness (IMT) in HCh children and also to investigate the relation between serum cholesterol levels and arterial stiffness. Materials and methods We determined lipid profile, body mass index, blood pressure, heart rate, carotid IMT and several arterial stiffness parameters, as β-index, elastic modulus (Ep), arterial compliance (AC), pulse wave velocity (PWV) and AIx, in 44 untreated HCh children (mean age 10·7 ± 2·8 years; 18 with familial hypercholesterolemia, FH, and 26 with primary hypercholesterolemia, PHC) and 18 age- and sex-matched controls. HCh children never received any medication, including antihypertensive and lipid lowering drugs. Results Respect to controls and to PHC, FH had significantly higher (P |
| Databáze: | OpenAIRE |
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