Age‐related differences in norfloxacin pharmacokinetic behaviour following intravenous and oral administration in sheep
| Autor: | Javier Nieto, M. L. de Vicente, Fernando Gil González, M. D. San Andrés, M. I. San Andrés, Casilda Rodríguez |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Aging Administration Oral Biological Availability Physiology Absorption (skin) Pharmacology Absorption Random Allocation Anti-Infective Agents Pharmacokinetics Oral administration Animals Medicine Distribution (pharmacology) Norfloxacin Cross-Over Studies Sheep General Veterinary business.industry Half-life Crossover study Bioavailability Injections Intravenous Female business Half-Life medicine.drug |
| Zdroj: | Veterinary Quarterly. 19:145-150 |
| ISSN: | 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.1997.9694760 |
| Popis: | The pharmacokinetics of norfloxacin after intravenous (i.v.) and oral (PO) administration in lambs (n = 5) and adult sheep (n = 5) were studied. After i.v. administration (10 mg.kg-1) plasma concentrations were best fitted by a three-compartment open model in both age groups. Distribution volumes were significantly larger in lambs (approximate 4.0 fold difference between 4 week old and adult sheep). There was no significant difference (p < 0.05) between the groups in terms of elimination halflife but plasma clearance was significantly higher in lambs. Norfloxacin was poorly absorbed after oral administration (60 mg.kg-1) in sheep (F = 4.04%). Mean oral bioavailability was 73.51% in lambs (30 mg.kg-1). Norfloxacin elimination was faster in lambs after oral administration. MRTt was significantly prolonged in both age groups when compared with the respective data for i.v. administration. |
| Databáze: | OpenAIRE |
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