Clinical impact and immunological alterations in asthmatic patients allergic to grass pollen subjected to high urban pollution in Madrid
| Autor: | Mariano Amo-Salas, Francisco Feo-Brito, Teresa Alfaya Arias, Cristobalina Mayorga, María Luisa Somoza Álvarez, José Miguel Urra Ardanaz, Elisa Haroun Díaz, Rubén Fernández Santamaría |
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| Rok vydání: | 2021 |
| Předmět: |
Pollution
Allergy media_common.quotation_subject Immunology Environmental pollution medicine.disease_cause Poaceae Pollen Grass pollen Environmental health Air Pollution otorhinolaryngologic diseases Immunology and Allergy Medicine Asthmatic patient Humans Asthma media_common Pollutant Air Pollutants business.industry food and beverages Allergens medicine.disease Seasons business Environmental Pollution |
| Zdroj: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyREFERENCES. 52(4) |
| ISSN: | 1365-2222 |
| Popis: | Background The prevalence of asthma has increased in recent decades. Among the reasons for this increase is environmental pollution. Pollutants cause bronchial inflammation and introduce modifications in the pollen, making it more allergenic. Objective Assess symptoms and medication requirements of asthmatic patients with grass allergies in Madrid (high urban pollution) and Ciudad Real (low pollution), and simultaneously evaluate the in vitro effects that pollen collected in both areas has on the immune cells of patients. Methods During two pollen seasons patients from both cities were included. The patients recorded their symptoms and the asthma medication they took daily. In both cities, pollen data, pollutants and meteorological variables were evaluated. The response to different cell populations from patients in both areas were analysed after "in vitro" stimulation with pollen from both cities. Results The symptoms and medication use of the patients in Madrid was 29.94% higher. The NO2 concentration in Madrid was triple that of Ciudad Real (33.4 vs. 9.1 µg/m3 of air). All other pollutants had very similar concentrations during the study period. Pollen from the high pollution area caused a significant enhancement of T-CD8+ and NK cells proliferation compared to pollen of low pollution area, independently of the patient's origin. Conclusion Asthmatic patients from Madrid have a worse clinical evolution than those from Ciudad Real because of higher levels of urban pollution, and this could be driven by the higher capacity of pollen of Madrid to activate T- CD8+ and NK cells. |
| Databáze: | OpenAIRE |
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