T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation
| Autor: | Annika C. Betzler, Jasmin Ezić, Tsima Abou Kors, Thomas K. Hoffmann, Thomas Wirth, Cornelia Brunner |
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| Rok vydání: | 2022 |
| Předmět: |
T-Lymphozyt
Transcription Genetic Trans-activators Immunology T cell differentiation Transkription Lymphocyte Activation T-Lymphocytes Helper-inducer Mice Immunology and Allergy BOB.1/OBF.1 Animals ddc:610 B-Lymphocytes Humorale Immunität Germinal center Cell Differentiation Germinal Center Immunity Humoral Pou2af1 Helferzelle Trans-Activators Transcriptional co-activator Follicular T helper cells DDC 610 / Medicine & health Transkription Transcription Factors |
| Zdroj: | Frontiers in immunology. 13 |
| ISSN: | 1664-3224 |
| Popis: | The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the complete absence of germinal centers (GCs). This defect was mainly attributed to the defective B cell compartment. However, it is unknown whether and how BOB.1/OBF.1 expression in T cells contributes to the GC reaction. To finally clarify this question, we studied the in vivo function of BOB.1/OBF.1 in CD4+ T and follicular T helper (TFH) cell subpopulations by conditional mutagenesis, in the presence of immunocompetent B lymphocytes. BOB.1/OBF.1 deletion in CD4+ T as well as TFH cells resulted in impaired GC formation demonstrating that the impaired GC reaction described for conventional BOB.1/OBF.1-deficient mice cannot exclusively be traced back to the B cell compartment. Furthermore, we show a requirement of BOB.1/OBF.1 for T helper (TH) cell subsets, particularly for TFH cell differentiation. publishedVersion |
| Databáze: | OpenAIRE |
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