Growth Hormone Insensitivity Syndromes: Lessons Learned and Opportunities Missed
| Autor: | Caroline K. Buckway, Ron G. Rosenfeld |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
GH Receptor Human Growth Hormone Endocrinology Diabetes and Metabolism Growth factor medicine.medical_treatment Receptor molecule Drug Resistance Receptors Somatotropin Syndrome Biology Growth hormone Phenotype Endocrinology Somatomedins Metabolic effects Internal medicine Mutation Pediatrics Perinatology and Child Health medicine Growth Hormone Insensitivity Syndrome Humans |
| Zdroj: | Hormone Research in Paediatrics. 55:36-39 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000063472 |
| Popis: | The concept of growth hormone (GH) insensitivity has evolved since the condition was originally identified in 1966, and we now know that the primary defect involved is in the GH receptor. Cloning of the receptor molecule has led to great progress in our understanding of GH insensitivity (GHI) and its therapy, including the roles of GH and insulin-like growth factor I (IGF-I) in growth and development, and the relationships between height and serum levels of GH, IGF-I and their binding proteins. Despite the success of work on GHI and IGF-I, a number of opportunities have been missed in the past. The differences between the metabolic effects of GH and IGF-I are not fully understood, while measurements of IGF-I and IGF-binding protein 3 are perhaps not the ideal means of diagnosing GHI. Finally, the use of IGF-I to treat GHI has a number of limitations, and work is underway to develop alternative therapies. |
| Databáze: | OpenAIRE |
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