Effects of DM-9384, a pyrrolidone derivative, on alcohol- and chlordiazepoxide-induced amnesia in mice
| Autor: | Keiko Tohyama, Toshitaka Nabeshima, Tsutomu Kameyama |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Flumazenil
Male Scopolamine Clinical Biochemistry Amnesia Pharmacology Bicuculline Toxicology Biochemistry Chlordiazepoxide Mice Behavioral Neuroscience Muscarinic acetylcholine receptor Avoidance Learning medicine Animals Drug Interactions Biological Psychiatry Ethanol GABAA receptor Chemistry Antagonist Retention Psychology Pyrrolidinones Aniracetam carbohydrates (lipids) nervous system lipids (amino acids peptides and proteins) medicine.symptom Neuroscience Central Nervous System Agents medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 36:233-236 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(90)90396-y |
| Popis: | The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative. Pretraining administration of DM-9384 attenuated ethanol- and CDP-induced amnesia, whereas aniracetam failed to do so. The effects of DM-9384 on CDP-induced amnesia were antagonized by bicuculline, a GABAA receptor antagonist, but not by scopolamine, a muscarinic acetylcholine receptor antagonist and flumazenil, a benzodiazepine receptor antagonist. These results suggest that DM-9384 attenuates CDP-induced amnesia by interacting with the GABAergic neuronal system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|