A New Class of CYP1B1 Inhibitors Derived from Bentranil

Autor:	Lan Yi, Xinyue Huang, Meixian Yang, Jiajing Cai, Jianhua Jia, Zhiping Peng, Zhenghuan Zhao, Fengyuan Yang, Dachuan Qiu
Rok vydání:	2022
Předmět:	Organic Chemistry Clinical Biochemistry Drug Discovery Pharmaceutical Science Molecular Medicine Molecular Biology Biochemistry
Zdroj:	Bioorganicmedicinal chemistry letters.
ISSN:	1464-3405
Popis:	Cytochrome P450 1B1 (CYP1B1) is highly expressed in a variety of tumors and implicated to drug resistance. More and more researches have suggested that CYP1B1 is a new target for cancer prevention and therapy. Various CYP1B1 inhibitors with a rigid polycyclic skeleton have been developed, such as flavonoids, trans-stilbenes, and quinazolines. To obtain a new class of CYP1B1 inhibitors, we designed and synthesized a series of bentranil analogues, moreover, IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270f36b16076093279d112e08e8d8a28 https://pubmed.ncbi.nlm.nih.gov/36565966 Zobrazit plný text záznamu Full Text from ScienceDirect