Transcriptional regulation of repressor synthesis in mycobacteriophage L5
| Autor: | Chadd E. Nesbit, Margaret E. Levin, Graham F. Hatfull, Mary K. Donnelly‐Wu |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Gene Expression Regulation
Viral Transcription Genetic viruses Recombinant Fusion Proteins Molecular Sequence Data Repressor Biology Microbiology Polymerase Chain Reaction Mycobacterium Viral Proteins Bacteriolysis Lysogen Lysogenic cycle Transcriptional regulation Amino Acid Sequence RNA Messenger Promoter Regions Genetic Molecular Biology Lysogeny Regulation of gene expression Genetics Base Sequence Mycobacterium smegmatis Gene Expression Regulation Bacterial Mycobacteriophages biochemical phenomena metabolism and nutrition biology.organism_classification Temperateness DNA-Binding Proteins Repressor Proteins Lytic cycle Mutagenesis RNA Viral |
| Zdroj: | Molecular microbiology. 17(6) |
| ISSN: | 0950-382X |
| Popis: | Mycobacteriophage L5 is a temperate phage of the mycobacteria that forms stable lysogens in Mycobacterium smegmatis. Lysogeny is maintained by the putative repressor, the gene 71 product, which also mediates immunity to superinfection. We show here that there are three promoters located upstream of gene 71 which are active in an L5 lysogen but which do not require any phage-encoded proteins. In early lytic growth, gene 71 is also transcribed from a promoter, Pleft, located at the right end of the genome and which appears to be a target of gp71 regulation. A model is given for the regulation of L5 life cycles. |
| Databáze: | OpenAIRE |
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