Assignment of the structural genes for the ? subunit of hexosaminidase A, mannosephosphate isomerase, and pyruvate kinase to the region q22-qter of human chromosome 15
| Autor: | C. J. Chern, E. Engel, Roger H. Kennett, Carlo M. Croce, W.J. Mellman |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Mannose-6-Phosphate Isomerase
Genetic Linkage Somatic cell Pyruvate Kinase Structural gene Chromosomal translocation General Medicine Hybrid Cells Biology biology.organism_classification Molecular biology Translocation Genetic Chinese hamster Chromosome 17 (human) Chromosome 15 Hexosaminidases Genes Genetics Humans Hexosaminidase Carbohydrate Epimerases beta 2-Microglobulin Chromosomes Human 13-15 Pyruvate kinase |
| Zdroj: | Somatic Cell Genetics. 3:553-560 |
| ISSN: | 1572-9931 0098-0366 |
| DOI: | 10.1007/bf01539065 |
| Popis: | Concordant segregation of the expression of the alpha subunit of human hexosaminidase A, human mannosephosphate isomerase, and pyruvate kinase was observed in somatic cell hybrids between either thymidine kinase-deficient mouse cells or thymidine kinase-deficient Chinese hamster cells and human white blood cells carrying a translocation of the distal half (q 22-qter) of the long arm of chromosome 15 to chromosome 17. A positive correlation was established between the expression of these human phenotypes and the presence of the distal half of the long arm of human chromosome 15. |
| Databáze: | OpenAIRE |
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