Telomere length and cognitive function: Differential patterns across sociodemographic groups
| Autor: | Shari R. Waldstein, Danielle Shaked, Alan B. Zonderman, Nan-ping Weng, Daniel K. Leibel, Hans B. Liu, Danielle L. Beatty Moody, Michele K. Evans |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Trail Making Test Neuropsychological Tests Verbal learning Article White People 050105 experimental psychology Benton Visual Retention Test Executive Function Cognition Memory Memory span Humans Verbal fluency test Attention 0501 psychology and cognitive sciences Effects of sleep deprivation on cognitive performance Poverty 05 social sciences Middle Aged Telomere Cognitive test Black or African American Neuropsychology and Physiological Psychology Free recall Mental Recall Leukocytes Mononuclear Female Psychology Demography |
| Zdroj: | Neuropsychology |
| ISSN: | 1931-1559 0894-4105 |
| Popis: | OBJECTIVE The present study investigates whether associations between telomere length (TL) and cognitive performance across multiple domains are moderated by poverty status and race. METHOD Participants were 325 African American and White urban-dwelling adults (M age = 47.9 years; 49.5% African American; 50.2% female; 48.9% living in poverty) from the Healthy Aging in Neighborhoods of Diversity across the Life Span study. TL was assayed from peripheral blood mononuclear cells using quantitative polymerase chain reactions. Multivariable regression analyses examined interactions of TL, poverty status, and race with performance on the following cognitive tests: Trail-Making Test Parts A and B, Digit Span Forward and Backward, semantic verbal fluency, Brief Test of Attention, Benton Visual Retention Test (BVRT), and California Verbal Learning Test-II total learning, short-delay free recall, and long-delay free recall scores. Analyses adjusted for age, sex, and high school-or-greater educational attainment. RESULTS Significant three-way interactions of TL × Poverty Status × Race revealed that, among White participants living in poverty, shorter TL was associated with worse performance on Digit Span Forward and Backward (ps |
| Databáze: | OpenAIRE |
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