Comparative anti-phlogistic activity of Δ9-tetrahydrocannabinol, hydrocortisone and aspirin in various rat paw edema models
| Autor: | S D Nalepa, H B Vassar, L C Knobloch, R D Sofia |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Hydrocortisone Anti-Inflammatory Agents Pharmacology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Edema mental disorders medicine Animals Dronabinol General Pharmacology Toxicology and Pharmaceutics Mode of action Aspirin organic chemicals Rats Inbred Strains General Medicine Effective dose (pharmacology) Rats Carrageenan Dextran chemistry Serotonin medicine.symptom medicine.drug |
| Zdroj: | Life Sciences. 15:251-260 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(74)90214-8 |
| Popis: | The anti-edema activity of THC has been directly compared to that of hydrocortisone and aspirin in rat paw edemas produced by eleven different phlogistic agents. A significant effective dose for THC could only be achieved in carrageenan, dextran, formalin, kaolin and Na urate induced edemas, while hydrocortisone and aspirin were active against all edemas except that produced by serotonin. Based on these data it is suggested that the anti-edema effects of THC most likely occur by a different mode of action than either the classic steroid or non-steroidal anti-inflammatory agents. |
| Databáze: | OpenAIRE |
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