The Effects of Repeated Administration of the Micellar Complex of Methylprednisolone on the Locomotor Activity of a Terrestrial Snails
| Autor: | T. V. Batlina, Irina B. Deryabina, Andrianov Vv, Kh. L. Gainutdinov, M. V. Moiseeva, M. E. Baltin, M. I. Kamalov, D. I. Silant’eva |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Polymers Snail Pharmacology Locomotor activity Methylprednisolone General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine biology.animal Hemolymph Foot muscles Medicine Animals Glucocorticoids Micelles Drug Carriers biology business.industry Helix Snails Muscles General Medicine 030104 developmental biology business 030217 neurology & neurosurgery Locomotion medicine.drug Muscle Contraction |
| Zdroj: | Bulletin of experimental biology and medicine. 170(1) |
| ISSN: | 1573-8221 |
| Popis: | We studied the effects of repeated injections of methylprednisolone and its micellar complex with block-copolymer on locomotor activity of a terrestrial snail. It was shown that methylprednisolone solution injected into the hemolymph of the animal produced a direct effect on the muscle system of the animal as soon as 1 h after administration: it slowed down snail locomotion and reduced contractile activity of the foot muscles. The micellar complex of methylprednisolone with block-copolymer prevented this effect during the first 2 days of injection and negatively affected locomotion only in 2 days after injection, the decrease in locomotion in this case was not accompanied by a decrease in contractile activity of the foot muscle. |
| Databáze: | OpenAIRE |
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