Metachronous extragastrointestinal stromal tumor (EGIST) in utero: Report of an unusual case
| Autor: | Facundo Mandojana, Diana A. Pantoja Pachajoa, René M. Palacios Huatuco, Alejandro M. Doniquian, Matías Parodi, Rafael Palencia |
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| Rok vydání: | 2020 |
| Předmět: |
Leiomyosarcoma
medicine.medical_specialty Stromal cell Uterus Case Report Metachronous 03 medical and health sciences 0302 clinical medicine medicine Stromal tumor Mesentery GiST biology business.industry CD117 medicine.disease digestive system diseases medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Pelvic tumor 030211 gastroenterology & hepatology Surgery Radiology Gastrointestinal stromal tumor business GIST |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • GIST is the most common mesenchymal neoplasm of the digestive tract. • Have been described in the mesentery, omentum, gallbladder, bladder wall, and uterus (EGIST). • EGISTs are extremely rare and are usually detected incidentally. • This is the first reported case of a metachronous EGIST in utero. Introduction The gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the digestive tract. Currently, GIST is the name given to CD117 positive mesenchymal tumors, primary of the digestive tract, mesentery, and retroperitoneum. Nevertheless, they have been reported in the mesentery, omentum, gallbladder, bladder wall, and few cases in the uterus; known as extragastrointestinal stromal tumors (EGIST). Presentation of case Seventy-six-year-old woman with a history of the third recurrence of pelvic tumor located in the uterus initially diagnosed as uterine leiomyosarcoma. CT and MRI showed a tumor in the uterine corpus of approximately 10 cm. It was decided to perform the surgical rescue. The immunohistochemistry and anatomic pathology report revealed a tumor compatible with a uterine EGIST. It was decided to perform adjuvant treatment with imatinib. Currently, the patient continues to be disease-free 20 months after the surgery. Discussion For years, GIST has often been confused with leiomyosarcoma, given that they are histologically almost indistinguishable. The IHC analysis for KIT (CD117) has become essential in the GIST diagnosis. On the other hand, stromal tumors arising outside the gastrointestinal tract are rare (5%), which have a histological and biological behavior similar to that of GISTs. Conclusion EGISTs are extremely rare and often incidentally detected. Currently, evidence about this location is scarce. According to the literature, this is the first case of uterine EGIST with a metachronous presentation. |
| Databáze: | OpenAIRE |
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