Diagnostic significance of microRNAs as novel biomarkers for bladder cancer: a meta-analysis of ten articles
| Autor: | Jia-Xing Yu, Guang-Yong Li, Zheng Feng, Chao Zhang, Jian-Xiu Yu, Rui-Ning Zhao, Xiaobo Yang, Hong-Bin Shi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty lcsh:Surgery Diagnostic accuracy Urinalysis Bioinformatics lcsh:RC254-282 Likelihood ratios in diagnostic testing Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine microRNA Diagnosis medicine Biomarkers Tumor Odds Ratio Humans Prospective cohort study Neoplasm Staging miRNA Bladder cancer Receiver operating characteristic business.industry Research Nuclear Proteins lcsh:RD1-811 Cystoscopy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease MicroRNAs Meta-analysis 030104 developmental biology ROC Curve Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Diagnostic odds ratio Regression Analysis Surgery business |
| Zdroj: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 15, Iss 1, Pp 1-10 (2017) |
| ISSN: | 1477-7819 |
| Popis: | Background Previous studies have revealed the importance of microRNAs’ (miRNAs) function as biomarkers in diagnosing human bladder cancer (BC). However, the results are discordant. Consequently, the possibility of miRNAs to be BC biomarkers was summarized in this meta-analysis. Methods In this study, the relevant articles were systematically searched from CBM, PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI). The bivariate model was used to calculate the pooled diagnostic parameters and summary receiver operator characteristic (SROC) curve in this meta-analysis, thereby estimating the whole predictive performance. STATA software was used during the whole analysis. Results Thirty-one studies from 10 articles, including 1556 cases and 1347 controls, were explored in this meta-analysis. In short, the pooled sensitivity, area under the SROC curve, specificity, positive likelihood ratio, diagnostic odds ratio, and negative likelihood ratio were 0.72 (95%CI 0.66–0.76), 0.80 (0.77–0.84), 0.76 (0.71–0.81), 3.0 (2.4–3.8), 8 (5.0–12.0), and 0.37 (0.30–0.46) respectively. Additionally, sub-group and meta-regression analyses revealed that there were significant differences between ethnicity, miRNA profiling, and specimen sub-groups. These results suggested that Asian population-based studies, multiple-miRNA profiling, and blood-based assays might yield a higher diagnostic accuracy than their counterparts. Conclusions This meta-analysis demonstrated that miRNAs, particularly multiple miRNAs in the blood, might be novel, useful biomarkers with relatively high sensitivity and specificity and can be used for the diagnosis of BC. However, further prospective studies with more samples should be performed for further validation. |
| Databáze: | OpenAIRE |
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