In Silico and In Vivo Toxicological Evaluation of Paeonol
| Autor: | Yogesh A. Kulkarni, Kaveri M. Adki, Sankaranarayanan Murugesan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Maximum Tolerated Dose In silico medicine.medical_treatment Administration Oral Bioengineering Urine Pharmacology 01 natural sciences Biochemistry Rats Sprague-Dawley chemistry.chemical_compound In vivo medicine Animals Molecular Biology Behavior Animal Molecular Structure 010405 organic chemistry Chemistry Acetophenones General Chemistry General Medicine Acute toxicity Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry Toxicity Molecular Medicine Female Histopathology Paeonol |
| Zdroj: | Chemistry & Biodiversity. 17 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.202000422 |
| Popis: | Paeonol is a phenolic compound reported for its various pharmacological activities such as antioxidant, anti-inflammatory and antidiabetic activity. There are no systematic scientific reports on the in vivo toxicity of paeonol. So, the present work was designed to study in silico and in vivo toxicity of paeonol. In silico toxicity predictions were carried out using pkCSM, ProTox-II, pre-ADMET server and OSIRIS property explorer. Acute oral toxicity study of paeonol was carried out in female Sprague Dawley rats at a single dose of 300 mg/kg, 2000 mg/kg and 5000 mg/kg. Animals were observed for toxicity signs and mortality for 14 days. Repeated dose oral toxicity study of paeonol was carried out in female and male Sprague Dawley rats at a dose of 50, 100 and 200 mg/kg body weight for 28 days. At the end of the study, hematological, biochemical and urine parameters were assessed. Histopathology of vital organs was also carried out. In silico toxicity study predicted that paeonol is non-toxic. The maximally tolerated dose of paeonol was found to be 5000 mg/kg in acute toxicity study in female rats. Paeonol was found to be safe at a dose of 50, 100 and 200 mg/kg in repeated dose toxicity study in male and female rats. |
| Databáze: | OpenAIRE |
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