Biotransformation and toxicity of inhalational anaesthetics
| Autor: | Osafumi Yuge, Michio Morio, Kohyu Fujii |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
chemistry.chemical_compound Cytochrome P-450 Enzyme System Risk Factors medicine Humans Anesthetics business.industry Enflurane General Medicine Hypoxia (medical) Anesthesiology and Pain Medicine chemistry Isoflurane Liver Anesthesia Toxicity Inactivation Metabolic medicine.symptom Halothane Xenobiotic business Anesthesia Inhalation Anaerobic exercise Drug metabolism medicine.drug |
| Zdroj: | Canadian journal of anaesthesia = Journal canadien d'anesthesie. 37(4 Pt 2) |
| ISSN: | 0832-610X |
| Popis: | In summary, anaesthetics and drugs used perioperatively are all xenobiotics and can be metabolized mainly by microsomal enzyme systems, which have a high activity in the liver. These enzyme systems are induced by repeated pre-administration of drugs, such as barbiturates and others which are used during the preoperative period. However, according to some reports, aerobic and anaerobic metabolism is inhibited by the simultaneous administration of drugs, such as isoflurane and halothane, halothane and enflurane, and cimetidine and halothane. Hypoxia is also an important factor in hepatic disorders and it is well known that anaerobic metabolism of halothane is increased by hypoxia and its intermediate production produces a free radical. Theoretically, this free radical is involved in hepatic disorders. In practice, in order to prevent hepatic dysfunction before, during and after anaesthesia, hypoxia and repeated pre-administration of enzyme-inducing drugs should be avoided. However, the choice and combination of drugs which inhibit drug metabolism and prevent hepato and/or nephro toxicity should be examined by further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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