Mechanisms of small intestinal adaptation
| Autor: | A.P. Jenkins, R.P.H. Thompson |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cell division
Intestinal Secretions Gastroenterology Enteroglucagon General Medicine Biology Adaptation Physiological Small intestine Gastrointestinal Hormones Mediator medicine.anatomical_structure Intestinal mucosa Epidermal growth factor Immunology Intestine Small medicine Polyamines Animals Humans Intestinal Mucosa Cell Division Hormone |
| Zdroj: | Digestive diseases (Basel, Switzerland). 12(1) |
| ISSN: | 0257-2753 |
| Popis: | Luminal nutrition, hormonal factors and pancreaticobiliary secretions are probably the major mediators of small intestinal adaptation. Their actions, as discussed in this paper, are likely to be interrelated. Direct local enterotrophic effects cannot account for all the actions of luminal nutrients. Additionally, hormonal factors have been shown to contribute to indirect effects of luminal nutrients and enteroglucagon is a likely mediator of adaptive responses. Furthermore, epidermal growth factor is a peptide for which there is convincing evidence of an enterotrophic action. Attention is drawn to the fact that pancreaticobiliary secretions may have a physiological role in stimulating small intestinal mucosal proliferation. Other factors may also influence small intestinal mucosal proliferation (e.g. prostaglandins, neurovascular mechanisms, bacteria). Additionally, polyamines are crucial in initiating cell division in the small intestine, but the detailed mechanisms of their action require further clarification. Finally, a number of therapeutic applications of small intestinal epithelial cell proliferation are discussed. |
| Databáze: | OpenAIRE |
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