The error negativity in nonmedicated and medicated patients with Parkinson’s disease
| Autor: | Michel Panisset, Sidney J. Segalowitz, Calvin Melmed, Brigitte Stemmer, Jane Dywan |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Decision Making Neuropsychological Tests Audiology Antiparkinson Agents Central nervous system disease Degenerative disease Dopamine Physiology (medical) Reaction Time medicine Humans Attention Evoked Potentials Aged Aged 80 and over Analysis of Variance Dopaminergic Electroencephalography Parkinson Disease Middle Aged medicine.disease Sensory Systems Surgery Electrophysiology Drug-naïve medicine.anatomical_structure Neurology Case-Control Studies Scalp Female Neurology (clinical) Psychology Photic Stimulation Psychomotor Performance medicine.drug |
| Zdroj: | Clinical Neurophysiology. 118:1223-1229 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2007.02.019 |
| Popis: | Objective It has been hypothesized that the error negativity (Ne or ERN) is modulated by the midbrain dopaminergic system. Thus, in a depleted dopaminergic system as seen in patients with Parkinson’s disease (PD) one would expect an attenuated Ne. However, studies investigating the error negativities in medicated patients with PD have produced contradictory results and the present study was designed to explore this relationship further. Methods Using the event-related potential technique and an Eriksen flanker paradigm, we examined error negativities in nonmedicated (drug naive) and medicated PD patients and compared them to those of healthy controls. Results (a) The error negativities of the nonmedicated and medicated PD patients were attenuated compared to those of healthy elderly controls at frontocentral scalp sites; and (b) nonmedicated and medicated PD patients produced error negativities similar to each other. Conclusions PD results in diminished error negativities both in the early stage nonmedicated patients and in the later stage medicated patients. Significance Because both patient groups have reduced dopaminergic functioning compared to healthy controls, these findings are consistent with Ne amplitude being sensitive to modulations in that system. |
| Databáze: | OpenAIRE |
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