Simultaneous liquid chromatography-tandem mass spectrometry analysis of brominated flame retardants (tetrabromobisphenol A and hexabromocyclododecane diastereoisomers) in French breast milk
| Autor: | Virginie Rigourd, Frédéric Hommet, François Bordet, Chanthadary Inthavong, Thierry Guérin, Sylviane Dragacci |
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| Rok vydání: | 2017 |
| Předmět: |
Environmental Engineering
010504 meteorology & atmospheric sciences Health Toxicology and Mutagenesis Polybrominated Biphenyls 010501 environmental sciences Isotope dilution Mass spectrometry 01 natural sciences chemistry.chemical_compound Liquid chromatography–mass spectrometry Limit of Detection Tandem Mass Spectrometry Environmental Chemistry Humans 0105 earth and related environmental sciences Flame Retardants Detection limit Hexabromocyclododecane Chromatography Milk Human Extraction (chemistry) Public Health Environmental and Occupational Health General Medicine General Chemistry Pollution Hydrocarbons Brominated chemistry Maternal Exposure Environmental chemistry Tetrabromobisphenol A Female France Breast feeding Chromatography Liquid |
| Zdroj: | Chemosphere. 186 |
| ISSN: | 1879-1298 |
| Popis: | TBBPA and HBCDs are the two classes of flame retardants that are still allowed for use by the European Commission. In May 2013, HBCDs were listed as Persistent Organic Pollutants under the Stockholm Convention, and they were banned with an exemption on EPS/XPS for cavity wall insulation. This study describes the development and optimisation of a rapid LC-ESI-MS/MS method using isotopic dilution quantification including a simplified extraction step using a mixture of solvents and sulphuric acid hydrolysis followed by the one-shot analysis of TBBPA and each of the α-, β- and γ-HBCD diastereoisomers. The limits of detection and quantification (LOD and LOQ) were 0.5 and 2.5 ng g−1 (lipid weight, lw) for TBBPA and HBCD diastereoisomers, respectively. The method was applied to analyse 106 samples of individual mature breast milk. TBBPA was quantified in 42% of these samples within a range of |
| Databáze: | OpenAIRE |
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