An Innovative Hydrogen Peroxide-Sensing Scaffold and Insight Towards its Potential as an ROS-Activated Persulfide Donor
Autor: | S. Israel Suarez, Madison A. Kalk, John C. Lukesh, Rynne A. Hankins, Nolan M. Green, Megan N. Harty |
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Rok vydání: | 2020 |
Předmět: |
chemistry.chemical_classification
Scaffold Reactive oxygen species Cell signaling 010405 organic chemistry Hydrogen sulfide chemistry.chemical_element General Medicine General Chemistry 010402 general chemistry medicine.disease_cause 01 natural sciences Sulfur Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Electrophile medicine Hydrogen peroxide Oxidative stress |
Zdroj: | Angewandte Chemie (International ed. in English). 59(49) |
ISSN: | 1521-3773 |
Popis: | Reactive sulfur species, such as hydrogen sulfide, persulfides, and polysulfides, have recently emerged as key signaling molecules and important physiological mediators within mammalian systems. To better assess the therapeutic potential of their exogenous administration, we report on the development of a unique hydrogen peroxide (H2 O2 )-sensing motif and its capacity for providing cellular protection against oxidative stress while serving as a reactive oxygen species (ROS)-activated persulfide donor. With the strategic implementation of a gem-dimethyl group to promote both stability and cyclization, we found the initial rate of payload release from this newly derived scaffold to be directly proportional to the concentration of H2 O2 and to proceed via an unprecedented pathway that avoids the production of electrophilic byproducts, a severe limitation that has plagued the physiological application of previous designs. |
Databáze: | OpenAIRE |
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