Hydrate of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulo-2,6-pyranose as new crystalline reagent in the preparation of Amadori derived peptides
| Autor: | Monika Kijewska, Piotr Stefanowicz, Tadeusz Lis, Zbigniew Szewczuk, Hubert Bartosz-Bechowski, Joanna Batorska |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
amadori products
Stereochemistry Chemistry General Chemistry Nuclear magnetic resonance spectroscopy Crystal structure Medicinal chemistry solid phase synthesis Solid-phase synthesis Pyranose Reagent Amadori rearrangement Materials Chemistry x-ray studies Isostructural Hydrate QD1-999 2 3:4 5-di-o-isopropylidene-β-d-arabino-hexos-2-ulo-2 6-pyranose |
| Zdroj: | Open Chemistry, Vol 8, Iss 1, Pp 28-33 (2010) |
| ISSN: | 2391-5420 |
| Popis: | We established, that crystalline hydrate of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulo-2,6-pyranose is a new, convenient and stable reagent for solid phase synthesis of peptide derived Amadori products. The structure of the title compound was studied by X-ray analysis, NMR spectroscopy, and high resolution ESI-MS. The crystal structure indicated the existence of two symmetry-independent molecules that were not connected with hydrogen bonds. A comparison with previously reported 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose revealed, that these two compounds are isostructural. |
| Databáze: | OpenAIRE |
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