Longitudinal Assessment of Quality of Life in Patients With Type 2 Diabetes and Self-Reported Erectile Dysfunction
| Autor: | Maurizio Belfiglio, Giorgia De Berardis, Gianni Tognoni, Maria Chiara Rossi, Monica Franciosi, Sheldon Greenfield, Miriam Valentini, Barbara Di Nardo, Michele Sacco, Sherrie H. Kaplan, Antonio Nicolucci, Fabio Pellegrini |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Gerontology Research design medicine.medical_specialty Longitudinal study Time Factors Endocrinology Diabetes and Metabolism Context (language use) Type 2 diabetes Erectile Dysfunction Quality of life Surveys and Questionnaires Internal medicine Internal Medicine medicine Humans Longitudinal Studies Depression (differential diagnoses) Aged Advanced and Specialized Nursing Chi-Square Distribution business.industry Middle Aged medicine.disease Health Surveys Erectile dysfunction Diabetes Mellitus Type 2 Italy Quality of Life business Chi-squared distribution |
| Zdroj: | Diabetes Care. 28:2637-2643 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.28.11.2637 |
| Popis: | OBJECTIVE—In the context of the QuED (Quality of Care and Outcomes in Type 2 Diabetes) project, we evaluated the longitudinal changes over 3 years in quality of life (QoL) in patients with type 2 diabetes according to the presence or the development of erectile dysfunction (ED). RESEARCH DESIGN AND METHODS—Patients were requested to fill in a questionnaire investigating the presence of ED and QoL (SF-36 Health Survey, depression symptoms [Center for Epidemiologic Studies–Depression], and quality of sexual life) every 6 months for 3 years. The analyses were based on multilevel models, adjusted for patient clinical and sociodemographic characteristics. RESULTS—The study involved 1,456 patients, of whom 34% reported frequent erectile problems at baseline; 192 developed ED during the follow-up. No changes in QoL measures were detected in patients without ED; in those with ED at baseline, a worsening in all SF-36 scales was observed, reaching statistical significance for physical functioning (P = 0.03). Among patients who developed ED during the study, a deterioration in all SF-36 dimensions and a worsening in depressive symptoms preceded the development of ED. The onset of ED was associated with a further marked worsening in physical functioning (P = 0.0008), general health perception (P = 0.02), and social functioning (P = 0.04) on SF-36 subscales, as well as in the summary physical and mental components scores (P = 0.04 and P = 0.07, respectively). The development of ED was also associated with a highly significant increase in depressive symptoms (P = 0.001) and a marked decrease in quality of sexual life (P < 0.0001). CONCLUSIONS—This longitudinal study documents for the first time the impact of ED onset on several aspects of QoL in patients with type 2 diabetes. The study also shows that QoL tended to further decrease during 3 years in patients with ED at baseline but not in those without this condition. |
| Databáze: | OpenAIRE |
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