Rash in a Patient Treated with Pemetrexed for Relapsed Non-small Cell Lung Cancer
| Autor: | Isabelle Declercq, Yolande Lievens, Eric Verbeken, Johan Vansteenkiste |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Pulmonary and Respiratory Medicine
Chemotherapy medicine.medical_specialty medicine.diagnostic_test Radiotherapy business.industry medicine.medical_treatment Induction chemotherapy Pemetrexed medicine.disease Rash Surgery Radiation therapy medicine.anatomical_structure Oncology Non-small cell lung cancer Skin biopsy medicine medicine.symptom business Lung cancer Thoracic wall medicine.drug |
| Zdroj: | Journal of Thoracic Oncology. (6):662-663 |
| ISSN: | 1556-0864 |
| DOI: | 10.1097/JTO.0b013e318170fcb9 |
| Popis: | 66-year-old man was treated with platinum-based induction chemotherapy (three cycles) followed by thoracic radiotherapy for stage IIIB non-small cell lung cancer. Because of the extent of the disease, high-dose thoracic radiotherapy was not feasible, and 36 Gy/3 Gy fractions on the originally involved areas, with a boost of 12 Gy/3 Gy to the region of residual uptake on positron emission tomography scan after chemotherapy was given. Six months after the initial therapy, the patient experienced anorexia, thoracic pain and cough, based on a local relapse. Administration of the first cycle of second-line pemetrexed (after standard premedication) was complicated 5 days later by a painful, itchy, CTC-NCI grade 2, rash on the thoracic wall (Figure 1). The skin was red, warm, painful, and edematous in an area matching the radiation portal (Figure 2). A skin biopsy revealed a moderate perivascular infiltrate of lymphocytes and eosinophils of the superficial dermis and to a lesser extent of the deeper dermis, compatible with urticarial drug reaction (Figure 3). Treatment with local corticosteroids resulted in complete resolution of the rash within 3 days and the further pemetrexed administration was uneventful. |
| Databáze: | OpenAIRE |
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