Age-related heart rate response to exercise in heart transplant recipients. Functional significance
Autor: | Paolo Cerretelli, Guido Ferretti, Claudio Marconi, Filippo Mamprin, Mauro Marzorati, Roberto Fiocchi, Paolo Ferrazzi |
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Rok vydání: | 2002 |
Předmět: |
Male
Aging Physiology medicine.medical_treatment Clinical Biochemistry Settore BIO/09 - Fisiologia Oxygen Consumption/ physiology Heart Rate Heart reinnervation Heart rate response Physical Exertion/ physiology Heart transplantation Heart Middle Aged Control subjects Peripheral Muscle deterioration Gas exchange and heart rate kinetics Heart transplant recipients Peak VO Cardiology Functional significance Female Heart/innervation/physiology Adult medicine.medical_specialty Adolescent Physical Exertion Aging/ physiology Oxygen Consumption Physiology (medical) Internal medicine Age related Heart rate medicine Heart Rate/ physiology Humans Muscle Skeletal Exercise 2 business.industry Pulmonary Gas Exchange Surgery ddc:616.8 Muscle Skeletal/physiology CTL Heart Transplantation Pulmonary Gas Exchange/physiology business Peak VO2 |
Zdroj: | 443 (2002): 698–706. info:cnr-pdr/source/autori:Marconi C., Marzorati M., Fiocchi R., Mamprin F., Ferrazzi P., Ferretti G., Cerretelli P./titolo:Age-related heart rate response to exercise in heart transplant recipients. Functional significance/doi:/rivista:/anno:2002/pagina_da:698/pagina_a:706/intervallo_pagine:698–706/volume:443 Pflügers Archiv, Vol. 443, No 5-6 (2002) pp. 698-706 |
ISSN: | 0031-6768 |
Popis: | The heart rate (HR) and O(2) uptake (VO(2)) responses to cycle ergometer exercise and the role of O(2) transport in limiting submaximal and maximal aerobic performance were assessed in 33 heart transplant recipients (HTR) [14 children (P-HTR), 11 young adults (YA-HTR) and 8 middle-age adults (A-HTR)] and in 28 age-matched control subjects (CTL). In 7 P-HTR ("responders") the HR response to the onset of exercise (on-response) was as fast as that of CTL, whereas in all other patients ("non-responders") the HR on-response was typical of the denervated heart. Compared with non-responder P-HTR, responder P-HTR were also characterized by a normal peak HR (177+/- 16 vs. 151+/- 25 beats/min), an equally slow time constant for the VO(2) on-response (tau: 54 +/- 11 vs. 62+/- 13 s) and a similar low (approximately 60% of that of CTL) peak VO(2) (28 +/- 7 vs. 26 +/- 10 ml/kg per min). On the other hand non-responder YA-HTR and A-HTR were characterized by a relatively low peak HR (151 +/- 21 and 144 +/- 29 beats/min, respectively), a slow tau for the on-response (63 +/- 12 and 70 +/- 11 s) and a low peak (28 +/- 7 and 19 +/- 6 ml/kg per min). In conclusion, a sizeable number of paediatric patients (responder P-HTR) may reacquire the normal HR response to exercise, both in terms of kinetics and maximal level. Despite the almost complete recovery of cardiovascular function, and, probably, oxygen delivery, both the kinetics of the VO(2) on-response and the maximal aerobic power of the responder P-HTR were similar to those of non-responder P-HTR. The latter finding is probably attributable to peripheral limitations, due to inborn and/or pharmacological muscle deterioration. |
Databáze: | OpenAIRE |
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