Age-related heart rate response to exercise in heart transplant recipients. Functional significance

Autor: Paolo Cerretelli, Guido Ferretti, Claudio Marconi, Filippo Mamprin, Mauro Marzorati, Roberto Fiocchi, Paolo Ferrazzi
Rok vydání: 2002
Předmět:
Male
Aging
Physiology
medicine.medical_treatment
Clinical Biochemistry
Settore BIO/09 - Fisiologia
Oxygen Consumption/ physiology
Heart Rate
Heart reinnervation
Heart rate response
Physical Exertion/ physiology
Heart transplantation
Heart
Middle Aged
Control subjects
Peripheral
Muscle deterioration
Gas exchange and heart rate kinetics
Heart transplant recipients
Peak VO
Cardiology
Functional significance
Female
Heart/innervation/physiology
Adult
medicine.medical_specialty
Adolescent
Physical Exertion
Aging/ physiology
Oxygen Consumption
Physiology (medical)
Internal medicine
Age related
Heart rate
medicine
Heart Rate/ physiology
Humans
Muscle
Skeletal
Exercise
2
business.industry
Pulmonary Gas Exchange
Surgery
ddc:616.8
Muscle
Skeletal/physiology
CTL
Heart Transplantation
Pulmonary Gas Exchange/physiology
business
Peak VO2
Zdroj: 443 (2002): 698–706.
info:cnr-pdr/source/autori:Marconi C., Marzorati M., Fiocchi R., Mamprin F., Ferrazzi P., Ferretti G., Cerretelli P./titolo:Age-related heart rate response to exercise in heart transplant recipients. Functional significance/doi:/rivista:/anno:2002/pagina_da:698/pagina_a:706/intervallo_pagine:698–706/volume:443
Pflügers Archiv, Vol. 443, No 5-6 (2002) pp. 698-706
ISSN: 0031-6768
Popis: The heart rate (HR) and O(2) uptake (VO(2)) responses to cycle ergometer exercise and the role of O(2) transport in limiting submaximal and maximal aerobic performance were assessed in 33 heart transplant recipients (HTR) [14 children (P-HTR), 11 young adults (YA-HTR) and 8 middle-age adults (A-HTR)] and in 28 age-matched control subjects (CTL). In 7 P-HTR ("responders") the HR response to the onset of exercise (on-response) was as fast as that of CTL, whereas in all other patients ("non-responders") the HR on-response was typical of the denervated heart. Compared with non-responder P-HTR, responder P-HTR were also characterized by a normal peak HR (177+/- 16 vs. 151+/- 25 beats/min), an equally slow time constant for the VO(2) on-response (tau: 54 +/- 11 vs. 62+/- 13 s) and a similar low (approximately 60% of that of CTL) peak VO(2) (28 +/- 7 vs. 26 +/- 10 ml/kg per min). On the other hand non-responder YA-HTR and A-HTR were characterized by a relatively low peak HR (151 +/- 21 and 144 +/- 29 beats/min, respectively), a slow tau for the on-response (63 +/- 12 and 70 +/- 11 s) and a low peak (28 +/- 7 and 19 +/- 6 ml/kg per min). In conclusion, a sizeable number of paediatric patients (responder P-HTR) may reacquire the normal HR response to exercise, both in terms of kinetics and maximal level. Despite the almost complete recovery of cardiovascular function, and, probably, oxygen delivery, both the kinetics of the VO(2) on-response and the maximal aerobic power of the responder P-HTR were similar to those of non-responder P-HTR. The latter finding is probably attributable to peripheral limitations, due to inborn and/or pharmacological muscle deterioration.
Databáze: OpenAIRE
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