Toward one-pot lipase-catalyzed synthesis of poly(ɛ-caprolactone) particles in aqueous dispersion
| Autor: | Thunyarat Pongtharankul, Alain Durand, Pranee Inprakhon, Lars O. Wiemann, Emmanuelle Marie, Volker Sieber, Pabhangkon Panlawan |
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| Přispěvatelé: | Publica, Mahidol University [Bangkok], Fraunhofer (Fraunhofer-Gesellschaft), Laboratoire de Chimie Physique Macromoléculaire (LCPM), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2014 |
| Předmět: |
epsilon-caprolactone
Magnetic Resonance Spectroscopy Aqueous dispersion Polyesters Ring-opening polymerization 02 engineering and technology Degree of polymerization 010402 general chemistry 01 natural sciences Lactones chemistry.chemical_compound Colloid and Surface Chemistry Chain-growth polymerization Polymer chemistry Physical and Theoretical Chemistry Lipase Caproates Candida biology [CHIM.ORGA]Chemical Sciences/Organic chemistry Surfaces and Interfaces General Medicine Enzymes Immobilized 021001 nanoscience & nanotechnology 0104 chemical sciences Kinetics [CHIM.POLY]Chemical Sciences/Polymers Monomer chemistry Polymerization biology.protein Precipitation polymerization 0210 nano-technology Ionic polymerization Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces Colloids and Surfaces B: Biointerfaces, Elsevier, 2014, 113, pp.254-260. ⟨10.1016/j.colsurfb.2013.09.011⟩ |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2013.09.011 |
| Popis: | International audience; The preparation of polyester particles using enzyme-catalyzed (lipase from Candida antarctica B. CALB) ring-opening polymerization of epsilon-caprolactone (epsilon-CL) in aqueous dispersion was demonstrated for the first time. Immobilization of CALB enabled a significant increase of the number-average degree of polymerization of epsilon-CL oligomers (up to 38) as compared to dissolved CALB (8 at the maximum). The nature and amount of lipase, as well as the nature of the support material were identified as key parameters controlling ring-opening polymerization of epsilon-CL in aqueous dispersion. In addition, the involvement of solubilized monomers in polymerization elementary reactions was demonstrated and the consequences on oligomers average length were detailed. An overall mechanism of lipase-catalyzed epsilon-CL polymerization in aqueous dispersion taking into account the colloidal nature of reaction medium was proposed on the basis of experimental results. |
| Databáze: | OpenAIRE |
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