Statin therapy reduces contrast-induced nephropathy: An analysis of contemporary percutaneous interventions
| Autor: | Michael O'Donnell, Sanjaya Khanal, Dean E. Smith, Eva Kline-Rogers, David Share, Mauro Moscucci, Nizar Attallah |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Urology Contrast-induced nephropathy Contrast Media Renal function Kidney Function Tests chemistry.chemical_compound Preoperative Care medicine Humans Prospective Studies Registries cardiovascular diseases Angioplasty Balloon Coronary Prospective cohort study Creatinine business.industry Percutaneous coronary intervention General Medicine Odds ratio Middle Aged medicine.disease Surgery chemistry Cardiovascular Diseases Multivariate Analysis Conventional PCI Female Kidney Diseases Hydroxymethylglutaryl-CoA Reductase Inhibitors business Kidney disease |
| Zdroj: | The American Journal of Medicine. 118:843-849 |
| ISSN: | 0002-9343 |
| Popis: | Purpose We sought to examine whether statin therapy before percutaneous coronary intervention results in reduction in contrast-induced nephropathy (CIN). Intravascular administration of contrast media can have nephrotoxic effects, particularly in patients with baseline renal insufficiency. Along with lowering serum cholesterol, statins have pleiotropic effects in the vasculature. The effect of statin use on CIN is unknown. Subjects and methods We studied 29409 patients who had both baseline preprocedure and peak postprocedure serum creatinine measured at the time of their percutaneous coronary intervention (PCI). Baseline demographics and creatinine profile before and after the procedure were compared between patients who received preprocedure statins and those who did not. CIN was defined as an increase in serum creatinine of ≤0.5 mg/dL. Results Baseline serum creatinine was similar between the two groups. When compared with patients who did not receive preprocedure statins, patients on preprocedure statins had a lower incidence of CIN (4.37 vs 5.93, P P = 0.03). After adjustments for comorbidities, preprocedure statin use was associated with a significant reduction in CIN (odds ration [OR] 0.87, 95% confidence interval [CI] 0.77–0.99, P = 0.03). Conclusions Preprocedure statin use is associated with significant reduction in CIN after contemporary PCI. This reinforces the need to initiate statin therapy before percutaneous coronary interventions. |
| Databáze: | OpenAIRE |
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