Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocyticleukemia and myelodysplastic syndrome
| Autor: | Yok L. Kwong, Wing Y. Au, Edmond S. K. Ma, Raymond Liang, A. Fung |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Acute promyelocytic leukemia Cancer Research Adolescent Biology medicine.disease_cause Gene Frequency Gene Duplication Proto-Oncogene Proteins hemic and lymphatic diseases Genetics medicine Humans Child neoplasms Molecular Biology Aged Mutation Therapy related Receptor Protein-Tyrosine Kinases Middle Aged medicine.disease Peripheral blood Leukemia Myeloid Acute fms-Like Tyrosine Kinase 3 Myelodysplastic Syndromes Cancer research Female Myelocytic leukemia FLT3 gene internal tandem duplication Flt3 itd |
| Zdroj: | Cancer Genetics and Cytogenetics. 149:169-172 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2003.07.007 |
| Popis: | FLT3 gene internal tandem duplication (ITD) and activating loop mutations (D835) were determined in 22 cases of therapy-related acute myelocytic leukemia/myelodysplastic syndrome (t-AML/MDS) and 102 cases of de novo AML/MDS. In t-AML/MDS, FLT3 ITD was absent, and D835 was found in only one case of therapy-related acute promyelocytic leukemia (APL). In de novo AML/MDS, however, FLT3 ITD and D835 were significantly more frequent (28 of 102 cases, P = 0.024) and were associated with high peripheral blood and marrow blast counts. Our results suggest that different pathogenetic pathways might be involved in t-AML/MDS and de novo AML/MDS. |
| Databáze: | OpenAIRE |
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