Stimulated echo diffusion tensor imaging (STEAM-DTI) with varying diffusion times as a probe of breast tissue
| Autor: | Tone Frost Bathen, Melanie Moccaldi Rt, Sungheon Kim, Eric E. Sigmund, Linda Moy, Jose R. Teruel, Pål Erik Goa, Thorsten Feiweier, Gene Y. Cho |
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| Rok vydání: | 2017 |
| Předmět: |
Breast tissue
Materials science business.industry Radial diffusivity Thermal diffusivity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance Fractional anisotropy Health insurance Radiology Nuclear Medicine and imaging Stimulated echo Diffusion (business) Nuclear medicine business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Magnetic Resonance Imaging. 45:spcone-spcone |
| ISSN: | 1053-1807 |
| DOI: | 10.1002/jmri.25586 |
| Popis: | Purpose To explore the application of diffusion tensor imaging (DTI) for breast tissue and breast pathologies using a stimulated-echo acquisition mode (STEAM) with variable diffusion times. Materials and Methods In this Health Insurance Portability and Accountability Act-compliant study, approved by the local institutional review board, eight patients and six healthy volunteers underwent an MRI examination at 3 Tesla including STEAM-DTI with several diffusion times ranging from 68.5 to 902.5 ms. A DTI model was fitted to the data for each diffusion time, and parametric maps of mean diffusivity, fractional anisotropy, axial diffusivity, and radial diffusivity were computed for healthy fibroglandular tissue (FGT) and lesions. The median value of radial diffusivity for FGT was fitted to a linear decay to obtain an estimation of the surface-to-volume ratio, from which the radial diameter was calculated. Results For healthy FGT, radial diffusivity presented a linear decay with the square root of the diffusion time resulting in a range of estimated radial diameters from 202 to 496 µm, while axial diffusivity presented a nearly time-independent diffusion. Residual fat signal was reduced at longer diffusion times due to the shorter T1 of fat. Residual fat signal to the overall signal in the healthy volunteers' FGT was found to range from 2.39% to 2.55% (shortest mixing time), and from 0.40% to 0.51% (longest mixing time) for the b500 images. Conclusion The use of variable diffusion times may provide an in vivo noninvasive tool to probe diffusion lengths in breast tissue and breast pathology, and might aid by improving fat suppression at longer diffusion times. Level of Evidence: 2 J. Magn. Reson. Imaging 2017;45:84–93. |
| Databáze: | OpenAIRE |
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