MRI Acquisition and Analysis Protocol for In Vivo Intraorbital Optic Nerve Segmentation at 3T
| Autor: | Claudia A. M. Wheeler-Kingshott, Ahmed T. Toosy, Rhian Raftopoulos, Raj Kapoor, Marios C. Yiannakas, David Miller |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Coefficient of variation Pilot Projects In vivo Image Processing Computer-Assisted medicine Humans Segmentation Protocol (science) 3 Tesla Magnetic Resonance Imaging Reproducibility Anatomy Cross-Sectional medicine.diagnostic_test business.industry Reproducibility of Results Optic Nerve Magnetic resonance imaging Magnetic Resonance Imaging Optic nerve Female Artifacts business Nuclear medicine Orbit |
| Zdroj: | Investigative Opthalmology & Visual Science. 54:4235 |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.13-12357 |
| Popis: | Purpose.: To present a new acquisition and analysis protocol for reliable and reproducible segmentation of the entire intraorbital optic nerve (ION) mean cross-sectional area by means of magnetic resonance imaging (MRI) at 3 tesla (T). / Methods.: Eight healthy volunteers (mean age 31, five were male) gave written informed consent and both of their IONs were imaged individually using a coronal-oblique T2-weighted fast multidynamic image acquisition scheme; the proposed acquisition scheme has its rationale in combining separately acquired volumes and registering them to account for motion-related artifacts commonly associated with longer acquisitions. Mean cross-sectional area of each ION was measured using a semiautomated image analysis protocol that was based on an active surface model previously described and used for spinal cord imaging. Reproducibility was assessed for repeated scans (scan-rescan) and repeated image analysis performance (intraobserver). / Results.: Mean and SD values of the left ION cross-sectional area for the eight healthy volunteers were 5.0 (±0.7) mm2 and for the right ION were 5.3 (±0.8) mm2. Mean scan-rescan coefficient of variation (COV) for the left ION was 4.3% and for the right was 4.4%. Mean intraobserver COV for the left ION was 2.1% and for the right was 1.8%. / Conclusions.: This study presents a new MRI acquisition and analysis protocol for reliable and reproducible in vivo measurement of the entire ION mean cross-sectional area as demonstrated in a pilot study of healthy subjects. The protocol presented here can be used in future studies of the ION in disease state. |
| Databáze: | OpenAIRE |
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