Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes
| Autor: | Sylvain Olivero, Eric Vivier, Anna Cambiaggi, Valery Renard, Mathieu Blery, Frédéric Vély, Lucia Olcese, Magali Bouchet |
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| Rok vydání: | 1997 |
| Předmět: |
Antibody-dependent cell-mediated cytotoxicity
Cytotoxicity Immunologic Cellular immunity Lymphokine-activated killer cell Effector Immunology Molecular Sequence Data Lymphokine Biology Lymphocyte Activation Natural killer cell Cell biology Killer Cells Natural medicine.anatomical_structure medicine Immunology and Allergy Cytotoxic T cell Animals Humans Amino Acid Sequence Receptors Immunologic Cytotoxicity Signal Transduction |
| Zdroj: | Immunological reviews. 155 |
| ISSN: | 0105-2896 |
| Popis: | Summary: NK-cells axe large granular lymphocytes, which are capable of exerting two major types of effector function, cell cytotoxicity and lymphokine secretion. NK -cells can exert cell cytotoxicity in one of two ways. First, NK-cells are able to recognize and to induce the lysis of antibody-coated target ceils during antibody-dependent cell cytotoxicity (ADCC). Second, during natural cytotoxicity NK cells are also able to recoginze to induce the lysis of a variety of target cell, including primarily virus-infected cells as well as tumor cells. Recently, a novel mechanism has been elucidated which controls NK-cell-activation programs and which is based on the cell surface expression of killer-cell inhibitory receptors (KIR). We will review here the molecular dissection of this inhibitory signalling pathway which utilizes immunoreceptor tyrosine-based inhibition motifs (ITIM) expressed in KIR intracytoplasmic domain. We will also show that this strategy used by NK-cells to regulate their effector functions a general decision mechanism which exists not only in T- and B-lymphocytes, but also in a variety of other hematopoietic cells. |
| Databáze: | OpenAIRE |
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