Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model

Autor: Hongchang Gao, Liangcai Zhao, Qingqing Xu, Junjie Yan, Yafei Zheng, Hangying Xu, Chen Li, Qiaoying Jiang, Hong Zheng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
endocrine system diseases
Lac
lactate
Hippocampus
Striatum
Hippocampal formation
Biochemistry
NAD+
nicotinamide adeninedinucleotide
0302 clinical medicine
Structural Biology
immune system diseases
Cortex (anatomy)
Tau
taurine
Cho
choline
0303 health sciences
Gly
glycine
Diabetes
Computer Science Applications
medicine.anatomical_structure
Hypothalamus
030220 oncology & carcinogenesis
Gln
glutamine
Cortex
Suc
succinate
Biotechnology
medicine.drug
Research Article
medicine.medical_specialty
Asp
aspartate
endocrine system
lcsh:Biotechnology
Biophysics
Biology
Ala
alanine
03 medical and health sciences
Diabetes mellitus
Internal medicine
lcsh:TP248.13-248.65
Genetics
medicine
GABA
γ-Aminobutyric acid
Metabolomics
Neurotransmitter
030304 developmental biology
ComputingMethodologies_COMPUTERGRAPHICS
Glu
glutamate
Myo
myo-inositol
nutritional and metabolic diseases
Gender
Streptozotocin
medicine.disease
ADP
adenosine diphosphate
IMP
inosine monophosphate
Cre/pCre
creatine/phosphocreatine
Endocrinology
Anaerobic glycolysis
AMP
adenosine monophosphate
Ino
inosine
NAA
N-acetylaspartate
Zdroj: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2063-2074 (2020)
Computational and Structural Biotechnology Journal
ISSN: 2001-0370
Popis: Graphical abstract
Highlights • Sex-specific metabolic differences occur in all brain regions of mice. • The hippocampal metabolism is more susceptible to T1D. • Metabolic disorders start at the cortex and hippocampus in female T1D mice. • Female mice show a hypometabolism status in the brain from normal to T1D. • T1D affects brain region-specific metabolic changes in a sex-specific manner.
Type 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported. Therefore, here we examined metabolic changes in six different brain regions of male and female mice under normal and T1D conditions using an integrated method of NMR-based metabolomics and linear mixed-model, and aimed to explore sex-specific metabolic changes from normal to T1D. The results demonstrate that metabolic differences occurred in all brain regions between two genders, while the hippocampal metabolism is more likely to be affected by T1D. At the 4th week after streptozotocin treatment, brain metabolic disorders mainly occurred in the cortex and hippocampus in female T1D mice, but the striatum and hippocampus in male T1D mice. In addition, anaerobic glycolysis was significantly altered in male mice, mainly in the striatum, midbrain, hypothalamus and hippocampus, but not in female mice. We also found that female mice exhibited a hypometabolism status relative to male mice from normal to T1D. Collectively, this study suggests that T1D affected brain region-specific metabolic alterations in a sex-specific manner, and may provide a metabolic view on diabetic brain diseases between genders.
Databáze: OpenAIRE
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