Sex‐Based Differences in Unrecognized Myocardial Infarction

Autor: Luis Eduardo Juarez-Orozco, Remco A. J. Schurer, Emelia J. Benjamin, M. Yldau van der Ende, Dirk J. van Veldhuisen, Erik Lipsic, Hindrik W. van der Werf, Harold Snieder, Ingmar Waardenburg, Pim van der Harst
Přispěvatelé: Life Course Epidemiology (LCE), Cardiovascular Centre (CVC)
Rok vydání: 2020
Předmět:
Male
sex differences
Time Factors
PROGNOSIS
Myocardial Infarction
030204 cardiovascular system & hematology
Electrocardiography
0302 clinical medicine
Epidemiology
Coronary Heart Disease
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Original Research
Netherlands
RISK
Incidence (epidemiology)
WOMEN
MEN
ASSOCIATION
Middle Aged
PREVALENCE
CARDIOVASCULAR-DISEASE
cardiovascular system
Female
epidemiology
Cardiology and Cardiovascular Medicine
Cohort study
Adult
medicine.medical_specialty
unrecognized myocardial infarction
Risk Assessment
03 medical and health sciences
Sex Factors
Predictive Value of Tests
Internal medicine
cohort study
medicine
Humans
cardiovascular diseases
Aged
Electrocardiology (ECG)
OLDER
Missed Diagnosis
business.industry
MORTALITY
Health Status Disparities
CARE
medicine.disease
Heart Disease Risk Factors
incidence
business
Zdroj: Journal of the American Heart Association, 9(13):015519. Wiley
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
DOI: 10.1161/jaha.119.015519
Popis: Background Myocardial infarction is an important cause of morbidity and mortality in both men and women. Atypical or the absence of symptoms, more prevalent among women, may contribute to unrecognized myocardial infarctions and missed opportunities for preventive therapies. The aim of this research is to investigate sex‐based differences of undiagnosed myocardial infarction in the general population. Methods and Results In the Lifelines Cohort Study, all individuals ≥18 years with a normal baseline ECG were followed from baseline visit till first follow‐up visit (≈5 years, n=97 203). Individuals with infarct‐related changes between baseline and follow‐up ECGs were identified. The age‐ and sex‐specific incidence rates were calculated and sex‐specific cardiac symptoms and predictors of unrecognized myocardial infarction were determined. Follow‐up ECG was available after a median of 3.8 (25th and 75th percentile: 3.0–4.6) years. During follow‐up, 198 women experienced myocardial infarction (incidence rate 1.92 per 1000 persons‐years) compared with 365 men (incidence rate 3.30; P P Conclusions A substantial proportion of myocardial infarctions are unrecognized, especially in women. Opportunities for secondary preventive therapies remain underutilized if myocardial infarction is unrecognized.
Databáze: OpenAIRE
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