Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature
| Autor: | D. Podeanu, Cristina Marian, Minerva Malau, Daniela Soanca, Simona Stolnicu, Erika Resetkova, Adela Nechifor Boila |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Adult Pathology medicine.medical_specialty medicine.drug_class Population Breast Neoplasms Biology Pathology and Forensic Medicine Malignant transformation Cytokeratin Immunophenotyping medicine Immunology and Allergy Humans education education.field_of_study Adenomyoepithelioma Myoepithelial cell General Medicine Middle Aged Cell Transformation Neoplastic Estrogen Hormone receptor Keratins Female |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 121(4) |
| ISSN: | 1600-0463 |
| Popis: | Two cases of adenomyoepithelioma of the breast with malignant transformation by monophasic population of cells are presented. The underlying benign adenomyoepithelioma with typical biphasic architectural pattern was identified and represented at least 30% of the tumor in each case. In both cases, malignant portion of tumor was composed of relatively uniform monophasic population of highly atypical cells. The malignant component in case 1 was positive for pan cytokeratin, myoepithelial markers, and basal-type cytokeratins and also focally positive for luminal-type of cytokeratins, but negative for hormone receptors (estrogen and progesterone) and HER-2/neu protein overexpression. The malignant component in case 2 was positive for spectrum of myoepithelial markers but negative for luminal cytokeratins, hormone receptors and HER-2/neu protein overexpression. The bilinear immunophenotype in the case 1 suggests that the malignant tumor may have developed from precursor multipotent cells that can differentiate into both luminal epithelial and myoepithelial cells, although malignant component in case 2 appears to be the of pure myoepithelial phenotype. |
| Databáze: | OpenAIRE |
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