Preclinical biomarkers of prion infection and neurodegeneration
| Autor: | Tze How Mok, Simon Mead |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Prions business.industry General Neuroscience Clinical study design Neurodegeneration Disease medicine.disease Clinical onset Prion Diseases Incubation period 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Prion infection Immunology Clinical endpoint Animals Medicine Biomarker discovery business Neuroscience Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Neurobiology. 61:82-88 |
| ISSN: | 0959-4388 |
| DOI: | 10.1016/j.conb.2020.01.009 |
| Popis: | Therapeutic strategies and study designs for neurodegenerative diseases have started to explore the potential of preventive treatment in healthy people, emphasising characterisation of biomarkers capable of indicating proximity to clinical onset. This need is even more pressing for individuals at risk of prion disease given its rarity which virtually precludes the probability of recruiting enough numbers for well powered preventive trials based on clinical endpoints. Experimental mouse inoculation studies have revealed a rapid exponential rise in infectious titres followed by a relative plateau of considerable duration before clinical onset. This clinically silent incubation period represents a potential window of opportunity for the adaptation of ultrasensitive prion seeding assays to define the onset of prion infection, and for neurodegenerative biomarker discovery through similarly sensitive digital immunoassay platforms. |
| Databáze: | OpenAIRE |
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